PARP1 interacts with HMGB1 and promotes its nuclear export in pathological myocardial hypertrophy
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چکیده
منابع مشابه
p53 SUMOylation promotes its nuclear export by facilitating its release from the nuclear export receptor CRM1
Chromosomal region maintenance 1 (CRM1) mediates p53 nuclear export. Although p53 SUMOylation promotes its nuclear export, the underlying mechanism is unclear. Here we show that tethering of a small, ubiquitin-like modifier (SUMO) moiety to p53 markedly increases its cytoplasmic localization. SUMO attachment to p53 does not affect its oligomerization, suggesting that subunit dissociation requir...
متن کاملHMGB1 and its physiological and pathological roles.
HMGB1 has been formerly known for its intracellular function - as the intranuclear non-histone DNA binding protein, which contributes to stabilization of nucleosomes, mediation of DNA bending and is regarded to have an essential position in DNA repair. Lately, its participation in innate and specific immune responses has been revealed. Passively released from necrotic cells or actively produced...
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چکیده ندارد.
Expressions of CD11a, CD11b, and CD11c integrin proteins in rats with myocardial hypertrophy
Objective(s):To examine the expressions of CD11a, CD11b, and CD11c integrins in the myocardial tissues of rats with isoproterenol-induced myocardial hypertrophy. This study also provided morphological data to investigate the signal transduction mechanisms of myocardial hypertrophy and reverse it. Materials and Methods: A myocardial hypertrophy model was established by subcutaneously injecting i...
متن کاملThe CRM1 nuclear export receptor controls pathological cardiac gene expression.
Diverse pathological insults trigger a cardiac remodeling process during which myocytes undergo hypertrophy, with consequent decline in cardiac function and eventual heart failure. Multiple transcriptional regulators of pathological cardiac hypertrophy are controlled at the level of subcellular distribution. For example, prohypertrophic transcription factors belonging to the nuclear factor of a...
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ژورنال
عنوان ژورنال: Acta Pharmacologica Sinica
سال: 2018
ISSN: 1671-4083,1745-7254
DOI: 10.1038/s41401-018-0044-4